Table 2 Methylation status of SSTR5-AS1 in LSCC tumor tissues
| Groups | N | Methylation frequency | |||
|---|---|---|---|---|---|
| Promoter | Exon 1 | ||||
| n (%) | P | n (%) | P | ||
| Age | |||||
| < 60 | 25 | 12(48.0) | 4(16.0) | ||
| ≥ 60 | 23 | 13(56.5) | 0.555 | 4(17.4) | 0.897 |
| Gender | |||||
| Male | 46 | 24(52.2) | 8(17.4) | ||
| Female | 2 | 1(50.0) | 0.952 | 0(0.0) | 0.518 |
| Smoking | |||||
| Negative | 10 | 4(40.0) | 2(20.0) | ||
| Positive | 38 | 21(55.3) | 0.390 | 6(15.8) | 0.751 |
| TNM stage | |||||
| I + II | 19 | 6(31.6) | 3(15.8) | ||
| III + IV | 29 | 19(65.5) | 0.021 | 5(17.2) | 0.895 |
| Pathological differentiation of tumor | |||||
| Well | 20 | 6(30.0) | 2(10.0) | ||
| Moderate | 16 | 10(62.5) | 3(18.7) | ||
| Poor | 12 | 9(75.0) | 0.028 | 3(25.0) | 0.525 |
| LN metastasis | |||||
| Negative (N0) | 22 | 7(31.8) | 3(13.6) | ||
| Positive (N1/2/3) | 26 | 18(69.2) | 0.010 | 5(19.2) | 0.604 |