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|
Groups
|
N
|
Protein expression
|
Methylation frequency (promoter)
|
Methylation frequency (Exon 1)
|
|---|
|
n (%)
|
P
|
n (%)
|
P
|
n (%)
|
P
|
|---|
|
Age
|
|
< 60
|
25
|
9 (36.0)
| |
4 (16.0)
| |
13 (52.0)
| |
|
≥ 60
|
23
|
7 (30.4)
|
0.683
|
5 (21.7)
|
0.611
|
14 (60.9)
|
0.536
|
|
Gender
|
|
Male
|
46
|
15 (32.6)
| |
9 (19.6)
| |
26 (56.5)
| |
|
Female
|
2
|
1 (50.0)
|
0.610
|
0 (0.0)
|
0.488
|
1 (50.0)
|
0.856
|
|
Smoking
|
|
Negative
|
10
|
4 (40.0)
| |
2 (20.0)
| |
5 (50.0)
| |
|
Positive
|
38
|
12 (31.6)
|
0.615
|
7 (18.4)
|
0.909
|
22 (57.9)
|
0.654
|
|
TNM stage
|
|
I + II
|
19
|
10 (52.6)
| |
3 (15.8)
| |
7 (36.8)
| |
|
III + IV
|
29
|
6 (20.7)
|
0.022
|
6 (20.7)
|
0.671
|
20 (68.9)
|
0.028
|
|
Pathological differentiation of tumor
|
|
Well
|
20
|
9 (45.0)
| |
3 (15.0)
| |
8 (40.0)
| |
|
Moderate
|
16
|
5 (31.3)
| |
3 (18.7)
| |
10 (62.5)
| |
|
Poor
|
12
|
2 (16.7)
|
0.252
|
3 (25.0)
|
0.782
|
9 (75.0)
|
0.128
|
|
LN metastasis
|
|
Negative (N0)
|
22
|
11 (50.0)
| |
4 (18.2)
| |
8 (36.4)
| |
|
Positive (N1/2/3)
|
26
|
5 (19.2)
|
0.024
|
5 (19.2)
|
0.926
|
19 (73.1)
|
0.011
|
